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Nurses Week: The Angels called Nurses

The trained nurse has become one of the great blessings of humanity taking a place beside the Physician and the the Priest...- William Osle...

New Alzheimer's Drug; Game Changer?


In what has been described as a possible game changer for patients suffering Alzheimer's disease, an experimental drug aducanumab given once a month for a year to patients in a clinical trial was found to clear the brain of protein (amyloid) plaques which are believed to play a key role in disrupting cellular processes and nerve cell communication processes in the brain. These plaques are commonly seen in aging brains but Alzheimer’s patients tend to have much more of these plaques.

One of the hallmarks of Alzheimer's disease is the accumulation 
of amyloid plaquesbetween nerve cells (neurons) in the brain

The study included 165 participants divided into 4 groups and treated with an intravenous infusion of either aducanumab or a placebo for over 54 weeks. The 4 groups of patients received 4 different doses of the experimental drug and PET brain scans showed reduction in plaques at all doses and duration with the greatest reduction observed in the highest dose group.

Of course, the fact that the study involved just a handful of patients is something to be mindful of before making any firm conclusions, as well as how much this plaque reduction translates to cognitive benefit for the patient. The researchers are mindful of the fact that many other Alzheimer’s drugs have appeared promising but never lived up.

It is known that these plaques begin to build up in Alzheimer’s patients’ years before the onset of symptoms. It is therefore encouraging that the plaques in the patients observed to have taken 20 years to accumulate were removed in a 12 month period.

Larger trials of drugs involving Alzheimer’s patients are in progress and are scheduled to run until 2020.

Medic-All 2016

The Physician, The Leader!


Lately I have been exposed like never before to the diversity of roles available in a medical team  in a developed country like the United States and this has made me wonder even more about the role of the Physicians as the "Head of the medical team" and leaders in the medical sector and the responsibilities that come with such leadership positions that most physicians have to imbibe rather than learn.
As Physicians, do we have to master all, to lead all?
I came across this interesting article on the "proper way for physicians to be leaders" by a Pathology resident one KevinMD.com, one of my favorite medical blogs and I thought i should share 
via Kevinmd.com, by Benjamin Mazer MD, MBA
In medical school, you learn very quickly that you can’t know everything. By the end of your first-year anatomy course, you’ll probably give up on learning the names of every part of the body, let alone the intricacies of how they function. As physicians, we must grow comfortable with our limitations. We seek help from our colleagues and try not to let our egos get in the way of patient care. We accept that no physician will ever master the entirety of his or her discipline.
But are physicians now expected to master other disciplines, such as software engineering and social work? If you read the popular press and even academic journals you may think so. I like to call this phenomenon, this growing body of subjects doctors “should” master, “Hippocratic capture.”
I was reminded of this new pressure most recently while reading this article in a New York Times blog. The author makes some excellent points. Medical curricula are relatively stagnant while our world rapidly changes. The best medicine will incorporate modern technology and respect for the socioeconomic factors that influence patients’ health. The author also complains that he sometimes feels as if he has only one tool in his toolbox: the biomedical framework. For many health problems, this feels like simply not enough.
It’s hard to imagine any physician not empathizing with this struggle. But is the solution for medical students to take design courses from a fine arts school, as the new Dell Medical School is planning (according to the NY Times blog)? Should doctors also become designers?
Doctors face the paradox of being among the most visible and respected members of the health care field. While this authority provides many rewards, it also places an enormous expectation on us as leaders of health care. Doctors are expected to heal the sick (and we want to). If socioeconomic struggles are leading to sickness, doctors are expected to fix that. If technology provides the opportunity to democratize health care, then doctors are expected to lead the charge. We’re even supposed to design better hospital gowns according to Dell Medical School’s example of its innovative new curriculum.
But to point out the obvious: We can’t do it all! Doctors have already come to terms with our inability to master the entirety of biomedical knowledge, and we need to come to terms with our inability to personally fix every social determinant of health or poorly-designed health system. In fact, we can better provide these influencers of health the respect they deserve by allowing the true experts to take charge.
There are millions of social workers, public health professionals, software engineers, designers, and others who have the ability and desire to improve people’s health through their respective disciplines. The solution isn’t for physicians to master yet another subject; it’s to build powerful interdisciplinary teams that can address these aspects of health care in an egalitarian manner by including many kinds of experts. Doctors and other providers can no longer be the only ones responsible to the public for creating the best possible health care system. This physician-dominant model is regressive and inefficient.
I am not suggesting that doctors should ignore problems outside of the biomedical framework. I personally attended business school in addition to medical school because I was excited by the opportunity to improve patients’ health through innovative health care delivery. But I went to business school precisely because I didn’t expect the intricacies of management and economics to be taught in medical school. I don’t expect all physicians to master this part of medicine.
I am suggesting that if doctors are expected to master the multitudinous disciplines that are relevant to health then eventually the biomedical aspect of medicine will suffer. After all, despite the need to address the social determinants of health, you still need someone who knows how to take out an appendix. In forward-thinking health circles, the “biomedical framework” has become an epithet. It represents the myopia of past physicians, who thought scientists in a lab would cure every disease, ignoring issues of poverty, education, and behavior. But biomedicine is still a vital part of good care delivery and should remain at the center of medical education.
While many types of professionals can address health care policy, good design, and innovative technology, only physicians have the duty to provide medical care under the biomedical framework. When someone requires a surgery or drug for their illness, it is doctors who are responsible for ensuring the proper selection and delivery of that type of care. We can dilute our education, but we cannot dilute that responsibility.
Doctors should have some familiarity with the many disciplines that affect health. This isn’t a new idea, despite what the popular press would lead you to believe. I attended the University of Rochester’s medical school, which since the 1970’s has been home to the “biopsychosocial model” of medicine. I greatly value the broad experiences I received from learning under this medical model. Even in this environment, however, I spent plenty of time learning the pathophysiology and technical skills that are traditional parts of medical education.
I personally look forward to addressing the business side of health care in addition to providing good medical care under the biomedical framework. When I do work on issues outside of this framework, however, I expect to succeed not by knowing everything there is to know about health care delivery, but by engaging administrators, engineers, and others through interdisciplinary teamwork. If physicians are expected to be leaders of the health care system, then this is the proper way to lead. Hippocrates, after all, didn’t need an MBA or MSW to be a good doctor.
Benjamin Mazer is a pathology resident and can be reached on Twitter at @BenMazeror at his self-titled site, Benjamin Mazer, MD, MBA.
Medic-ALL 2016

First U.S Uterus Transplant Fails

Medic-ALL (03:09:2016)

The first attempt at a womb transplant in the United States has failed after a sudden complication forced its removal about 2 weeks after the initial surgical operation.



The recipient, the 26 year old Lindsey, is however recovering well according to reports.

The technique is a new frontier that would hopefully one day offer woman born without a uterus or who lost their uterus to disease a chance of getting pregnant.

The failed transplant was the first of 10 planned by the Cleveland Clinic in a clinic trial, and the hospital said the study is continuing.

Medic-ALL Inc 2016

First Womb Transplant in the U.S


Medic-ALL (02-26-2016) MEDICAL BREAKTHROUGHS

About 5 months after the first baby was born from a transplanted womb in Sweden, a team of doctors at the Cleveland Clinic performed the first successful uterus transplant in the United States. 



On Wednesday, February 24, a 26 year old woman received the new womb courtesy of a deceased organ donor in a 9 hour operation. The womb will be removed once she has one or two babies. This will enable her to stop the medications she has to be on to prevent her body from rejecting the foreign organ-this is a huge risk that has led to failed procedures in the past. Her previously impossible pregnancy will now rely on in vitro fertilization (IVF), using her eggs (harvested prior to the transplant) that have been fertilized with her husband's sperm and then frozen.

As at Thursday, the patient was in stable conditions and will have to wait for about a year for the healing process to be complete before she has the IVF procedure. Also, a cesarean section will probably be the right option for delivery when the time comes to prevent any injury either to the mother or child.

Ref: CNN, Cleveland Clinic


Medic-ALL Inc 2016



What About the Zika Virus?

Medic-ALL (01-30-2016) DISEASES
by Kayode Kuku

I am probably not the only one to have noticed that the "short-named" viruses seem to be making all the headlines over the cancers and "mouthful-named" diseases. From the Ebola virus to Lassa, the last couple of years have witnessed deadly outbreaks of these viral hemorrhagic fevers in different parts of the world...meaning we should be taking them seriously. 

Humans are infected through the bite of an infected Aedes Mosquito



What about the Zika virus?
Over the last couple of weeks, the Zika virus has been spreading aggressively throughout Latin America and with global infection rates rising, the world is very much at alert to learn more about the emerging disease.

Zika virus is a mosquito-borne viral disease that was first identified in rhesus monkeys in Uganda, East Africa in 1947 through a monitoring network set up for yellow fever at the time (Zika belongs to the same viral family-Flavivirus as the yellow fever and dengue virus). It was subsequently found in humans in Uganda and Tanzania 5 years later. Since then outbreaks have been recorded in the Americas, Africa, Asia and the Pacific.

It is spread primarily through the bite of an infected Aedes mosquito (which usually bites during the morning and late afternoon/evening hours.

Playing odds... you probably would not know if you were bitten and got infected, because only 1 out of 5 people develop symptoms...How Nice! The incubation period is thought to be about a few days and those who develop symptoms get fever, red eyes, rash, headache  joint pain,  and malaise which resolve within a week.Oh then, Whats all the noise about right??

Not as friendly in Pregnant women
Micocephaly is a  devastating condition
The Zika virus has been associated with miscarriages and birth defects, specifically microcephaly which is characterized by severe mental and physical disability in the newborn. That to me would mean, that ladies who are pregnant or intend to get pregnant should not be heading towards countries like  Brazil, Colombia, El Salvador, French Guiana, Guatemala, Haiti, Honduras, Martinique, Mexico, Panama, Paraguay, Suriname, Venezuela, and Puerto Rico at this time. 




Precautions however
First is to do all you can not to get bitten by a mosquito. Application of insect repellents as well as wearing of protective clothing, (since Aedes bites in daylight as well) will definitely be beneficial if travelling to the tropics or any of the affected nations. Your Doctor may also consider prophylactic medications. 

Those infected are advised to get plenty of rest , drink adequate amount of fluids and treat pain and fever with  common medications. No vaccines are available presently.


Even though Zika is not some new virus, there is still a lot to learn regarding our understanding of the virus, its association with other medical conditions and other dangers to pregnancy especially with its continuing spread to new areas and rising worldwide concerns.


Refs: KevinMD, WHO






Lassa Outbreak in Nigeria..Months and counting

Medic-ALL (01-25-2016) DISEASE

by Kayode Kuku


Just less than 2 years after the Ebola virus hit the Nigeria and other countries in the West African region, Lassa fever, another viral hemorrhagic fever, with similar symptoms as Ebola broke out in the country.

Lassa fever is an acute viral illness first discovered in Nigeria in 1969 when 2 missionary nurses died from the disease. The virus was subsequently named after the town in Borno State, Nigeria where the first cases occurred. The virus belongs to the virus family, Arenaviridae, a single stranded RNA virus which is animal borne and usually associated with rodent transmitted diseases in humans.

It is endemic in parts of West Africa including Sierra Leone, Gambia, Liberia and Nigeria notably but the risk is spread throughout the region where the disease vector, the multimammate rat (Mastomys Natalensis) is distributed.
Lassa virus is transmitted to humans by contact with excreta or urine of infected rats.

Lassa virus is transmitted to humans by contact with food or household items which have been contaminated with excreta or urine of infected rats. Since the disease is endemic in rodent population, it tends to affect communities with poor sanitation and crowded living conditions the most. Hence it is sometimes referred to as a "disease of the poor".

The present outbreak of Lassa Fever broke out in Nigeria, August 2015 and reports show that it has claimed up to 63 lives as at the January, 24, 2016  out of over 200 suspected cases spread across 17 states in the country including the Federal Capital Territory, Abuja. Nigeria's Health Minister, Professor Isaac Adewole, stated that 212 suspected cases have been reported in the last 3 months.

While the world's most populous black nation was praised for its prompt containment of Ebola in 2014, things appear a little more complicated in the case of Lassa , as many stakeholders including specialists have raised concerns ranging from ignorance of the disease among the vulnerable communities, leading to under-reporting of the cases and under-mining the scale of the outbreak  , and even the capacity of the country's healthcare system to deal with the outbreak at this time.

These are valid concerns, considering the "skeletal" state of the country's primary health care system and the lack of access to adequate health care in the vulnerable regions. The country reported 112 deaths and over 1700 cases of Lassa fever in 2012, yet in a population of over 170 million people, there is only one research center in the country to cater for Lassa fever research.

As far as comparison with Ebola goes, Lassa fever is not necessarily as deadly, but it spreads faster.

Meanwhile, while Lassa fever has exposed the level of preparedness of the nation's health care system to cope with such outbreaks, the WHO and US CDC are working with Nigeria Health Ministry in containing the outbreak.

Medic-All Inc. 2016

Refs: CDC, Punch Nigeria

Getting Started as a Physician Entrepreneur


Medic-ALL (01-18-2016) FEATURED POST
By Arlen Myers MD, Edited by Kayode Kuku

Medicine and entrepreneurship are not two words you will commonly find in the same sentence, but whether we like it or not Medicine and Healthcare are essential fields of human existence and hence should call for "good business" for stakeholders. This featured post highlights tips that can make a successful Physician Entrepreneur out of most. 



Physician entrepreneurship has thankfully gone mainstream, to the benefit of patients, physician employers and other innovation stakeholders. While most physicians lack an entrepreneurial mindset, several are realizing their innerpreneur and want to take the next steps.But, like having a good idea, they don't know what to do next. Here are 10 tips that can help you on your journey:

1. Connections are Everything:  Connect to the right people and organizations in the nearest innovation ecosystem and begin to research potential areas of interest and opportunities. Seek partnerships at every stage of your career, they will come in handy in the future 

2. Build a Brand:  Start a personal branding campaign using social media and communication tools to make people aware of your interests and skills so they can find you. You have to be known for something. Doctors specialize for a reason 

3. Acquire Knowledge: Arm yourself with the education, resources, networks, mentors and experiential learning you will need to advance your entrepreneurial career

4. Be a Business-man: Set yourself up as a business entity and separate your personal finances from your business finances and activities

5.  Small Beginnings: Don't be scared to start right where you are. 

6. New ways: Seek new and more efficient ways.  There are many ways to practice physician entrepreneurship or intrapreneurship, so take a high level view. Create user defined values not companies.

7. Consult with networks:  Engage others who are like minded in your region to develop a community of interest. Talk to business schools, medical associations, economic development professionals,venture or angel networks,  industry associations or patient groups interested in advancing biomedical and clinical innovation and entrepreneurship

8. Mentoring: Those who have gone ahead and succeeded, do have a lot to share. Find a mentors or probable sponsors.

9. Learn the Ropes: There are always more brain cells to engage. Get as much business "clinical" experience as possible, realizing that the initials after your name really do not mean much. Start to come down off the mountain.

10. Pass it forward: Train others 

Don't expect everyone to welcome you with open arms. People WILL FEAR YOU OR HATE YOU.

So, may feel threatened , but as long as that little voice in your head whispering entrepreneurial sweet nothings seems to be getting louder and louder, take the next steps and enjoy the journey. With any luck, it will be a lengthy and successful one.


Edited by Kayode Kuku, MD,  CEO Medic-ALL blog 

Arlen Meyers, MD, MBA is the President and CEO of the Society of Physician Entrepreneurs at www.sopenet.org 

Medic-ALL Inc. 2016

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